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KMID : 0613820080180081173
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Journal of Life Science
2008 Volume.18 No. 8 p.1173 ~ p.1176
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Effect of ALDH2 Enzyme Activity on the Level of 8-Hydroxydeoxyguanosine in Tissues Following Ethanol Exposure
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Zhang Yan-Wei
Choi Sheung-Hee
Kim Yun-Sik
Moon Sun-In
Eom Sang-Yong
Kim Yong-Dae
Kim Heon
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Abstract
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Individuals who regularly consume excessive quantities of alcohol are at a greater risk of developing various cancers such as esophageal, pharyngeal and lung cancers compared to normal populations if they are deficient in ALDH2 enzyme activity. We evaluated oxidative DNA damage in the liver, brain, and lung tissues of Aldh2 +/+ and Aldh2 -/- mice after they had been subjected to acute ethanol exposure. The 8-hydroxydeoxyguanosine (8-OHdG) level in each tissue was evaluated as a biomarker of oxidative DNA damage. The 8-OHdG level in the liver, brain, and lung tissues was significantly increased following ethanol treatment. In addition, the level of 8-OHdG in the liver and lung tissues was affected by ALDH2 enzyme activity. This result suggests that ALDH2-deficient individuals may be more susceptible than wild-type ALDH2 individuals to ethanol-mediated diseases, including cancer.
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KEYWORD
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Aldehyde dehydrogenase 2, 8-hydroxydeoxyguanosine, oxidative stress, knockout mice
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